VR23 - Proteasome Inhibitor. CAS# 1624602-30-7 433 Smiles: COC1=CC(=CC=C1C(O)=O)NC1=NC2=C(CN=C(C3=C(F)C=CC=C3OC)C3=CC(Cl)=CC=C32)C=N1

Smiles: COC1=CC(=CC=C1C(O)=O)NC1=NC2=C(CN=C(C3=C(F)C=CC=C3OC)C3=CC(Cl)=CC=C32)C=N1

10(4):1072-81

RK-33 binds specifically to DDX3

potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models

Bardoxolone

VR23 - Proteasome Inhibitor. CAS# 1624602-30-7 433 Smiles: COC1=CC(=CC=C1C(O)=O)NC1=NC2=C(CN=C(C3=C(F)C=CC=C3OC)C3=CC(Cl)=CC=C32)C=N1VR23, CAS No. 1624602 30 7, is a potent and selective proteasome inhibitor with IC50 of 1 nM, 50 100 nM, and 3 M for trypsin like proteasomes, chymotrypsin like proteasomes, and caspase like proteasomes, respectively. Data from molecular docking and substrate competition assays established that the primary molecular target of VR23 was 2 of the 20S proteasome catalytic subunit. VR23 was structurally distinct from other known proteasome inhibitors and