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TMPA-AMPK Activator - CAS# 1258275-73-8 size:10mg solid 1801747-11-4

SKU: 68929360383

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Description

1801747-11-4

Formula: C22H28N4O2

Crenolanib has 25-fold more affinity for PDGFRA/B compared with KIT

68(11):882-8

Chemical Name: 7-(3

TMPA-AMPK Activator - CAS# 1258275-73-8 size:10mg solid 1801747-11-4TMPA, CAS No. 1258275 73 8, is a novel small molecule that binds to orphan Nuclear Receptor Nur77 with high affinity (Kd = 1. 45 0. 35 M), and interferes with the Nur77 LKB1 interaction. TMPAs binding to Nur77 results in the release and shuttling of LKB1 to the cytoplasm to phosphorylate AMPK. TMPA treatment can effectively reduce blood glucose and alleviate insulin resistance in type II db db and high fat diet and streptozotocin induced diabetic mice

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