BMS-1166-N-piperidine-COOH Catalog No.:M13983-2 Smiles: CC(NC(=O)C1=CC=CC=C1N=CC1=C(O)C=CC2=CC=CC=C21)C1C=CC=CC=1

Smiles: CC(NC(=O)C1=CC=CC=C1N=CC1=C(O)C=CC2=CC=CC=C21)C1C=CC=CC=1

10(39):318-24

It acts by promoting glioblastoma cancer stem-like cell differentiation by activating NF-κB

4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4

6-tetrahydropyrimidin-4-yl)-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3

BMS-1166-N-piperidine-COOH Catalog No.:M13983-2 Smiles: CC(NC(=O)C1=CC=CC=C1N=CC1=C(O)C=CC2=CC=CC=C21)C1C=CC=CC=1BMS 1166 N piperidine COOH, the BMS 1166 based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD 1 PD L1 degrader 1 (HY 131183) to degrade PD 1 PD L1. BMS 1166 is a potent PD 1 PD L1 interaction inhibitor with an IC50 of 1. 4 nM. BMS 1166 antagonizes the inhibitory effect of PD 1 PD L1 immune checkpoint on T cell activation. Product information CAS Number: 2447066 00 2 Molecular Weight: 639. 14 Formula: C37H35ClN2O6 Chemical Name: 1 ({5