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GNE-781 modulates MYC expression that corresponds with antitumor activity in an AML tumor model
PF-04217903 phenolsulfonate also inhibits HGF-mediated cell migration and Matrigel invasion in several c-Met–overexpressing tumor cell lines such as human NCI-H441 lung carcinoma and HT29 colon carcinoma with IC50 values comparable with those for inhibition of c-Met phosphorylation in these cell lines (IC50=7-12
InChi: InChI=1S/C118H174N34O35S
InChiKey: GMRQFYUYWCNGIN-PEJFXWBPSA-N
InChiKey: HCFDWZZGGLSKEP-NPMXJOAUSA-N
RRx-001 7464 GNE-781 modulates MYC expression thatRRx 001, a hypoxia selective epigenetic agent and studied as a radio and chem sensitizer, triggers apoptosis and overcomes drug resistance in myeloma. RRx 001 exhibits potent anti tumor activity with minimal toxicity. RRx 001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP . RRx 001 is a potent inhibitor of G6PD and shows potent antimalarial activity. Product information CAS Number: 925206 65 1 Molecular Weight: 268. 02