HLI 373 dihydrochloride Catalog No.:M8040-10 demonstrating that phosphorylation of p53

demonstrating that phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

2-trichloro-1-(3-(4-fluoro-3-nitrophenyl)thioureido)ethyl)acetamide

65(Pt 5):449-61

1080/15384101

Solubility: DMSO: 100 mg/mL(108

HLI 373 dihydrochloride Catalog No.:M8040-10 demonstrating that phosphorylation of p53HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2 mediated ubiquitylation and proteasomal degradation of p53. HLI 373 induces apoptosis in several tumor cell lines that express wild type p53 such as LOX IMVI, A549, HT1080 and U2OS. Product information CAS Number: 1782531 99 0 Molecular Weight: 414. 33 Formula: C18H25Cl2N5O2 Chemical Name: 5 ((3 (dimethylamino)propyl)amino) 3, 10 dimethylpyrimido[4, 5 b]quinoline 2, 4(3H, 10H)