You can wipe them, but everybody takes 18 damage
The key is that her ability also reduces alternate and additional costs, so you also get a discount on awaken, kicker, overload, flashback, and buyback costs
This doesnt make them unplayable, but it does mean that they are only going to provide specific or supplemental support at best
Outside of something like Cranial Ram, though, there's not too much that's looking like it's going to be a major issue from the jump
The Phyrexian Dinosaur cant get countered and is difficult to remove once on the battlefield with a Ward of four
Fang, Roku's Companion It's asking too much for Fang, Roku's Companion to have a firebreathing effect, but the power boost is substantial