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Molecular Weight: 376
Guichard SM
24)14-2-1-3-16(10-14)25-20(28)26-19-11-17(32(29
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
Chemical Name: 2-(1-benzyl-4-hydroxy-2-oxo-1
PFI-3 - SMARCA Bromodomains Inhibitor. CAS# 1819363-80-8 Catalog No.:M60175-10S Molecular Weight: 376PFI 3, CAS No. 1819363 80 8, is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively. It also inhibits SMARCA2, but has no interaction with the other sub family branches including PB1(2 4) and a kinase panel of 36 kinases. It accelerates FRAP recovery in cells at a concentration of 1 M. The SWI SNF related, Matrix associated, Actin dependent Regulator of Chromatin (SMARC)